発表論文 Publications
#equal contribution. *corresponding author.
Preprint
Hoang H, Tsutsumi S, Matsuzaki M, Kano M, Toyama K., Kitamura K, Kawato M. Negative reward-prediction errors of climbing fiber inputs for cerebellar reinforcement learning algorithm. Biorxiv (2023) doi: 10.1101/2023.03.13.532374v1
2024
Yokoyama T, Manita S, Uwamori H, Tajiri M, Imayoshi I, Yagishita S, Murayama M, Kitamura K, Sakamoto M. A multicolor suite for deciphering population coding in calcium and cAMP in vivo. Nat. Methods (2024). doi: 10.1038/s41592-024-02222-9
Mochizuki T, Manita S, Shimura H, Kira S, Sawada N, Bito H, Sakimura K, Augustine GJ, Mitsui T, Takeda M, Kitamura K. Optogenetic stimulation of neurons in the anterior cingulate cortex induces changes in intravesical bladder pressure and the micturition reflex. Sci. Rep. 14, 6367 (2024). doi: 10.1038/s41598-024-56806-8
2023
#Hoang H, #Tsutsumi S, Matsuzaki M, Kano M, Kawato M, *Kitamura K, *Toyama K. Dynamic organization of cerebellar climbing fiber response and synchrony in multiple functional components reduces dimensions for reinforcement learning. eLife 12: e86340 (2023). doi: 10.7554/eLife.86340
#*Ikezoe K, #Hidaka N, Manita S, Murakami M, Tsutsumi S, Isomura Y, *Kano M, *Kitamura K. Cerebellar climbing fibers multiplex movement and reward signals during a voluntary movement task in mice. Commun. Biol. 6: 924 (2023). doi: 10.1038/s42003-023-05309-9
2022
*Manita S, Shigetomi E, Bito H, Koizumi S, *Kitamura K In Vivo Wide-Field and Two-Photon Calcium Imaging from a Mouse using a Large Cranial Window. J. Vis. Exp. 186: e64224 (2022). doi: 10.3791/64224
日本語の簡単な説明：https://www.usaco.co.jp/article/detail.html?itemid=1792&dispmid=610
*Manita S, Ikezoe K, *Kitamura K. A novel device of reaching, grasping, and retrieving task for head-fixed mice. Front. Neural Circuits 16: 842748 (2022). doi: 10.3389/fncir.2022.842748
Sakamoto M, Inoue M, Takeuchi A, Kobari S, Yokoyama T, Horigane S, Takemoto-Kimura S, Abe M, Sakimura K, Kano M, Kitamura K, Fujii H, Bito H. A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo. Cell Rep. Methods 2:100168 (2022). doi: 10.1016/j.crmeth.2022.100168
2021
Rupprecht P, Carta S, Hoffmann A, Echizen M, Blot A, Kwan AC, Dan Y, Hofer SB, Kitamura K, Helmchen F, Friedrich RW. A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging. Nat. Neurosci. 24:1324-1337(2021). doi: 10.1038/s41593-021-00895-5
2020
Hoang H, Sato M, Shinomoto S, Tsutsumi S, Hashizume M, Ishikawa T, Kano M, Ikegaya Y, Kitamura K, Kawato M, Toyama K. Improved hyperacuity estimation of spike timing from calcium imaging. Sci Rep. 10:17844 (2020). doi: 10.1038/s41598-020-74672-y
Nakajima S, Manita S, Yu G, Ishimaru K, Kono K, Kitamura K, Nakao A. Activation of the reward system ameliorates passive cutaneous anaphylactic reaction in mice. Allergy 75: 3275-3279 (2020). doi: 10.1111/all.14442
2019
*Tsutsumi S, Hidaka N, Isomura Y, Matsuzaki M, Sakimura K, *Kano M, *Kitamura K. Modular organization of cerebellar climbing fiber inputs during goal-directed behavior. eLife 8:e47021 (2019). doi: 10.7554/eLife.47021
Covered by Insight article: https://elifesciences.org/articles/52631
Nakao H, Kishimoto Y, Hashimoto K, Kitamura K, Yamasaki M, Nakao K, Watanabe M, Kano M, Kirino Y, Aiba A. mGluR1 in cerebellar Purkinje cells is essential for the formation but not expression of associative eyeblink memory. Sci Rep. 9(1):7353 (2019). doi: 10.1038/s41598-019-43744-z.
#Inoue M, #Takeuchi A, #Manita S, Horigane S-i, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M, Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, *Bito H. Rational engineering of XCaMPs, a multicolor GECI suite for in vivo imaging of complex brain circuit dynamics. Cell 177: 1346-1360 (2019). doi: 10.1016/j.cell.2019.04.007
2018
Mizuno H, Ikezoe K, Nakazawa S, Sato T, Kitamura K, Iwasato T. Patchwork-Type Spontaneous Activity in Neonatal Barrel Cortex Layer 4 Transmitted via Thalamocortical Projections. Cell Rep. 22: 123-135 (2018). doi: 10.1016/j.celrep.2017.12.012.
2017
Manita S, Miyakawa H, Kitamura K, Murayama M. Dendritic Spikes in Sensory Perception. Front. Cell Neurosci. 11: 26 (2017). doi: 10.3389/fncel.2017.00029. Review
Good JM, Mahoney M, Miyazaki T, Tanaka KF, Sakimura K, Watanabe M, Kitamura K, Kano M. Maturation of Cerebellar Purkinje Cell Population Activity during Postnatal Refinement of Climbing Fiber Network. Cell Rep. 21: 2066–2073 (2017). doi: 10.1016/j.celrep.2017.10.101
Nakai N, Nagano M, Saitow F, Watanabe Y, Kawamura Y, Kawamoto A, Tamada K, Mizuma H, Onoe H, Watanabe Y, Monai H, Hirase H, Nakatani J, Inagaki H, Kawada T, Miyazaki T, Watanabe M, Sato Y, Okabe S, Kitamura K, Kano M, Hashimoto K, Suzuki H, Takumi T. Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice. Sci Adv. 3(6):e1603001 (2017). doi: 10.1126/sciadv.1603001
2015
Tsutsumi S, Yamazaki M, Miyazaki T, Watanabe M, Sakimura K, *Kano M, *Kitamura K. Structure-function relationships between aldolase C/zebrin II expression and complex spike synchrony in the cerebellum. J Neurosci, 35: 843-852 (2015). doi: 10.1523/JNEUROSCI.2170-14.2015
Inoue M, Takeuchi A, Horigane SI, Ohkura M, Gengyo-Ando K, Fujii H, Kamijo S, Takemoto-Kimura S, Kano M, *Nakai J, *Kitamura K, *Bito H. Rational design of a high-affinity, fast, red calcium indicator R-CaMP2. Nat. Methods, 12: 64-70 (2015). doi: 10.1038/nmeth.3185.
before 2014
Masamizu Y, Tanaka YR, Tanaka YH, Hira R, Ohkubo F, Kitamura K, Isomura Y, Okada T, Matsuzaki M. Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task. Nat. Neurosci., 17: 987-994 (2014). doi: 10.1038/nn.3739
Tada M, Takeuchi A, Hashizume M, *Kitamura K, *Kano M. A highly sensitive fluorescent indicator dye for calcium imaging of neural activity in vitro and in vivo. Eur. J. Neurosci., 39:1720-1728 (2014). doi: 10.1111/ejn.12476
*Kitamura K, Kano M. Dendritic calcium signaling in cerebellar Purkinje cell. Neural Networks 47: 11-17 (2013). doi: 10.1016/j.neunet.2012.08.001. Review
Kawamura Y, Nakayama H, Hashimoto K, Sakimura K, *Kitamura K, *Kano M. Spike timing-dependent selective strengthening of single climbing fibre inputs to Purkinje cells during cerebellar development. Nat. Commun. 4:2732 (2013). doi:10.1038/ncomms3732
Ikezoe K, Mori Y, Kitamura K, Tamura H, Fujita I. Relationship between the local structure of orientation map and the strength of orientation tuning of neurons in monkey V1: a 2-photon calcium imaging study. J. Neurosci. 33: 16818-16827 (2013). doi: 10.1523/JNEUROSCI.2209-13.2013.
Hashizume M, Miyazaki T, Sakimura K, Watanabe M, *Kitamura K, *Kano M. Disruption of cerebellar microzonal organization in GluD2 (GluRδ2) knockout mouse. Front. Neural Circuits 7:130 (2013). doi: 10.3389/fncir.2013.00130.
Kawashima T, Kitamura K, Suzuki K, Nonaka M, Kamijo S, Takemoto-Kimura S, Kano M, Okuno H, Ohki K, Bito H. Functional labeling of neuronal ensemble and axonal projections in vivo using a synthetic activity-dependent promoter E-SARE. Nat. Methods, 10: 889-895 (2013). doi:10.1038/nmeth.2559
Fujii H, Inoue M, Okuno H, Sano Y, Takemoto-Kimura S, Kitamura K, Kano M, Bito H. Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. Cell Rep. 3: 978-987 (2013). doi: 10.1016/j.celrep.2013.03.033.
Hira R, Ohkubo F, Ozawa K, Isomura Y, Kitamura K, Kano M, Kasai H, Matsuzaki M. Spatiotemporal dynamics of functional clusters of neurons in the mouse motor cortex during a voluntary movement. J. Neurosci. 33: 1377-1390 (2013).
Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Ohkubo F, Kitamura K, Matsuzaki M, Sakai Y, Isomura Y. Reinforcing operandum: rapid and reliable learning of skilled forelimb movements by head-fixed rodents. J. Neurophysiol. 108: 1781-1792 (2012).
Nakayama H, Miyazaki T, Kitamura K, Hashimoto K, Yanagawa Y, Obata K, Sakimura K, Watanabe M, Kano M. GABAergic inhibition regulates developmental synapse elimination in the cerebellum. Neuron 74: 384-396 (2012).
Takahashi N, Kitamura K, Matsuo N, Mayford M, Kano M, Matsuki N, Ikegaya Y. Locally synchronized synaptic inputs. Science 335: 353-356 (2012).
*Kitamura K, *Häusser M. Dendritic calcium signaling triggered by spontaneous and sensory-evoked climbing fiber input to cerebellar Purkinje cells in vivo. J. Neurosci. 31: 10847-10858 (2011).
Hashimoto K, Tsujita M, Miyazaki T, Kitamura K, Yamazaki M, Shin HS, Watanabe M, Sakimura K, Kano M. Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum. Proc. Natl. Acad. Sci. USA 108: 9987-9992 (2011).
Noguchi J, Nagaoka A, Watanabe S, Ellis-Davies, GC, Kitamura K, Kano M, Matsuzaki M, Kasai H. In vivo two-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice. J. Physiol. 589: 2447-2457 (2011).
Hashimoto K, Ichikawa R, Kitamura K, Watanabe M, Kano M. Translocation of a ‘‘Winner’’ climbing fiber to the Purkinje cell dendrite and subsequent elimination of ‘‘Losers’’ from the soma in developing cerebellum. Neuron 63: 106-118 (2009).
Schultz SR, Kitamura K, Post-Uiterwee A, Krupic J, Häusser M. Spatial pattern coding of sensory information by climbing fiber-evoked calcium signals in networks of neighboring cerebellar Purkinje cells. J. Neurosci. 29: 8005-8015 (2009).
Judkewitz B, Rizzi M, Kitamura K, Häusser M. Targeted in vivo single-cell electroporation. Nat. Protoc. 4: 862 – 869 (2009).
#Kitamura K, #Judkewitz B, Kano M, Denk W, Häusser M. Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo. Nat. Methods 5: 61-67 (2008).
Tsukasaki Y, Kitamura K, Shimizu K, Iwane AH, Takai Y, Yanagida T. Role of multiple bonds between the single cell adhesion molecules, nectin and cadherin, revealed by high sensitive force measurements. J. Mol. Biol. 367: 996-1006 (2007).
Okada T, Tanaka H, Iwane AH, Kitamura K, Ikebe M, Yanagida T. The diffusive search mechanisms of processive myosin class-V motor involves directional steps along actin subunits. Biochem. Biophys. Res. Commun. 354: 379-384 (2007).
Loewenstein Y, Mahon S, Chadderton P, Kitamura K, Sompolinsky H, Yarom Y, Häusser M. Bistability of cerebellar Purkinje cells modulated by sensory stimulation. Nat. Neurosci. 8: 201-211 (2005).
Kitamura K, Tokunaga M, Esaki S, Iwane AH, Yanagida T. Mechanism of muscle contraction based on stochastic properties of single actomyosin motors observed in vitro. BIOPHYSICS 1: 1-19 (2005).
Ishii Y, Kitamura K, Tanaka H, Yanagida T. Molecular motors and single-molecule enzymology. Methods Enzymol. 361: 228-245 (2003).
*Kitamura K, Yanagida T. Stochastic properties of actomyosin motor. Biosystems 71: 101-110 (2003).
Kitamura K, Tokunaga M, Iwane AH, Yanagida T. A single myosin head moves along an actin filament with regular steps of 5.3 nanometres. Nature 397: 129-134 (1999).
Tokunaga M, Kitamura K, Saito K, Iwane AH, Yanagida T. Single molecule imaging of fluorophores and enzymatic reactions achieved by objective-type total internal reflection fluorescence microscopy. Biochem. Biophys. Res. Commun. 235: 47-53 (1997).
Iwane AH, Kitamura K, Tokunaga M, Yanagida T. Myosin subfragment-1 is fully equipped with factors essential for motor function. Biochem. Biophys. Res. Commun. 230: 76-80 (1997).
Aoki T, Hiroshima M, Kitamura K, Tokunaga M, Yanagida T. Non-contact scanning probe microscopy with sub-piconewton force sensitivity. Ultramicroscopy 70: 45-55 (1997).
Tokunaga M, Aoki T, Hiroshima M, Kitamura K, Yanagida T. Subpiconewton intermolecular force microscopy. Biochem. Biophys. Res. Commun. 231: 566-569 (1997).